Lab logo

Laboratory of
Ocular Biomechanics

University of Pittsburgh

Postdoc positions available

  • Research position in astrocyte and neuron mechanobiology (post-doctoral or research assistant). Details.

  • Postdoc in mechanics of fiber-based materials. Details.

Latest News

April/2018: New paper accepted

  • "Tortuous pore path through the glaucomatous lamina cribrosa" by Scientific reports.

  • In collaboration with Gadi Wollstein, Joel Schuman, Hiroshi Ishkawa, Larry Kagemann and the rest of the Glaucoma imaging group at New York University.

April/2018: New paper accepted

  • "Crimp around the globe: Patterns of collagen crimp across the corneoscleral shell" by Experimental eye research.

April/2018: New paper accepted

  • "Polarized light microscopy for 3D mapping of collagen fiber architecture in ocular tissues" by Journal of Biophotonics.

March/2018: New paper accepted

  • "Seeing the hidden lamina; Effects of exsanguination on the optic nerve head" by IOVS.

March/2018: New paper accepted

  • "Collagen fiber recruitment: a microstructural basis for the nonlinear response of the posterior pole of the eye to increases in intraocular pressure" by Acta Biomaterialia.

February/2018: New conference proceedings published

  • "Structured polarized light microscopy (SPLM) for mapping collagen fiber orientation of ocular tissue" by SPIE Proceedings.

February/2018: New conference proceedings published

  • "Measuring in-vivo and in-situ ex-vivo the 3D deformation of the lamina cribrosa microstructure under elevated intraocular pressure" by SPIE Proceedings.

  • In collaboration with Gadi Wollstein and Joel Schuman from New York University and Matthew Smith from the University of Pittsburgh.

February/2018: Good luck Andrew Voorhees!

  • Andrew was a post-doctoral fellow from May 2015 to February 2018. He will join Johnson & Johnson.

January/2018: Congratulations Bryn Brazile!

  • Has been awarded a Knights Templar Eye Foundation (US) travel grant to attend and present at the upcoming ARVO 2018 annual meeting in Hawaii later this year. His project is titled "Simultaneous in-situ visualization and quantification of lamina cribrosa collagen beams and capillaries at normal and elevated IOPs"

January/2018: Three podium presentations

  • SPIE Photonics West, San Francisco, California, Jan 27 - Feb 1, 2018.

Active projects
Click images for more info.

Why biomechanics of the eye?

In our daily lives we rarely think of the eye as a biomechanical structure. The eye, however, is a remarkably complex structure with biomechanics involved in many of its functions. For our eyes to be able to track moving objects, for example, requires a delicate balance of the forces exerted by several muscles. Forces are also responsible for deforming the lens and allow focusing. A slight imbalance between the forces and tissue properties may be enough to alter or even preclude vision. These effects may take place quickly or over long periods, even years. Understanding ocular biomechanics is therefore important for preventing and treating vision loss.

 

Eye diagram

Schematic cross-section through a human eye. Light enters the eye through the cornea, passes through the pupil, lens and vitreous humour and strikes the retina, where it is absorbed. Retinal nerve fibers transmit visual information to the brain. These fibers converge at the optic nerve head region, exit the eye through the scleral canal, and form the optic nerve. The lamina cribrosa is a porous structure spanning the scleral canal. The vitreous chamber is filled with the vitreous humor, which exerts a pressure, the intraocular pressure, on the surface of the retina. [Sigal et al. Biomech Model Mechanobiol, 8(2):85-98, Apr 2009] (adapted from an illustration from NIH)

 

Goals

The objective of the Laboratory of Ocular Biomechanics is to study the eye as a biomechanical structure. More specifically our work is aimed at identifying the causes of glaucoma, with the ultimate intention of finding a way to prevent vision loss.