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Laboratory of
Ocular Biomechanics

University of Pittsburgh

Latest News

Postdoc position in elastography and image registration

Postdoc or research assistant position in structured illumination

Congratulations Alexander Mace, Zeyu Tong and Jinxian Zhao

  • 2nd place in the Swanson School of Engineering Design Expo April 2016

New paper accepted

  • "Decreased lamina cribrosa beam thickness and pore diameter relative to distance from the central retinal vessel trunk"
    by IOVS (Investigative Ophthalmology and Visual Science). In collaboration with the Glaucoma Imaging Group.

Invited podium presentation

  • Department of Biomedical Engineering, The Ohio State University

Congratulations Andrew Voorhees

  • Awarded a second year of support from the Department of Ophthalmology's Interdisciplinary Visual Sciences Training Program

Congratulations Felipe Suntaxi

  • Awarded a 2016 Summer Research Internship By the Department of Bioengineering

Congratulations Ziyi Zhu

  • Awarded a 2016 Summer Research Fellowship By the Swanson School of Engineering

Two invited podium presentations

  • New York University Department of Ophthalmology and Tandon School of Engineering, New York NY, March 21, 2016

One podium and three poster presentations

  • McGowan Institute for Regenerative Medicine Annual Retreat, Farmington PA, March 6-8, 2016

New paper accepted

  • "Regionally Discrete Aqueous Humor Outflow Quantification Using Fluorescein Canalograms"
    by PLOS ONE. In collaboration with the Loewen lab.

Welcome Vikram Gomatam, PhD

  • Joined our laboratory as a visiting research fellow

Grant awarded

  • FY2016 Stimulating Pittsburgh Research in Geroscience (SPRIG)
    In Collaboration with Kevin Chan.

Congratulations Andrew Voorhees

  • Awarded a Knights Templar Eye Foundation Travel Grant.

Active projects
Click images for more info.

Why biomechanics of the eye?

In our daily lives we rarely think of the eye as a biomechanical structure. The eye, however, is a remarkably complex structure with biomechanics involved in many of its functions. For our eyes to be able to track moving objects, for example, requires a delicate balance of the forces exerted by several muscles. Forces are also responsible for deforming the lens and allow focusing. A slight imbalance between the forces and tissue properties may be enough to alter or even preclude vision. These effects may take place quickly or over long periods, even years. Understanding ocular biomechanics is therefore important for preventing and treating vision loss.

 

Eye diagram

Schematic cross-section through a human eye. Light enters the eye through the cornea, passes through the pupil, lens and vitreous humour and strikes the retina, where it is absorbed. Retinal nerve fibers transmit visual information to the brain. These fibers converge at the optic nerve head region, exit the eye through the scleral canal, and form the optic nerve. The lamina cribrosa is a porous structure spanning the scleral canal. The vitreous chamber is filled with the vitreous humor, which exerts a pressure, the intraocular pressure, on the surface of the retina. [Sigal et al. Biomech Model Mechanobiol, 8(2):85-98, Apr 2009] (adapted from an illustration from NIH)

 

Goals

The objective of the Laboratory of Ocular Biomechanics is to study the eye as a biomechanical structure. More specifically our work is aimed at identifying the causes of glaucoma, with the ultimate intention of finding a way to prevent vision loss.