Lab logo

Laboratory of
Ocular Biomechanics

University of Pittsburgh

Latest News

August/2019: New paper accepted

  • "Scleral structure and biomechanics" by Progress in retinal and eye research.

  • In collaboration with Craig Boote from Cardiff University, Rafael Grytz from University of Alabama Birmingham, Thao D. Nguyen from Johns Hopkins University and Michael JA Girard from the National University of Singapore.

July/2019: Good luck Bin Yang!

  • Bin will join Duquesne University as an Assistant professor. He was a post-doctoral fellow from July 2016.

July/2019: Congratulations Yi (Jason) Hua and Bryn Brazile!

  • Have been awarded a travel fellowships to attend the ISER/BrightFocus Glaucoma Symposium in Atlanta, GA this October.

June/2019: Congratulations Po-Yi Lee and Gosia Fryc!

  • Their abstracts to SB3C were selected as finalists of the PhD and BS-level competition.

June/2019: Three podium and three poster presentations

  • Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C), Seven Springs, PA, June 25-28, 2019.

June/2019: Congratulations Fengting Ji and Po-Yi Lee!

  • Both did very well in their PhD qualifying exams.

June/2019: Podium and poster presentations

  • 2019 Vision science research day. University of Pittsburgh.

Active projects
Click images for more info.

Why biomechanics of the eye?

In our daily lives we rarely think of the eye as a biomechanical structure. The eye, however, is a remarkably complex structure with biomechanics involved in many of its functions. For our eyes to be able to track moving objects, for example, requires a delicate balance of the forces exerted by several muscles. Forces are also responsible for deforming the lens and allow focusing. A slight imbalance between the forces and tissue properties may be enough to alter or even preclude vision. These effects may take place quickly or over long periods, even years. Understanding ocular biomechanics is therefore important for preventing and treating vision loss.

 

Eye diagram

Schematic cross-section through a human eye. Light enters the eye through the cornea, passes through the pupil, lens and vitreous humour and strikes the retina, where it is absorbed. Retinal nerve fibers transmit visual information to the brain. These fibers converge at the optic nerve head region, exit the eye through the scleral canal, and form the optic nerve. The lamina cribrosa is a porous structure spanning the scleral canal. The vitreous chamber is filled with the vitreous humor, which exerts a pressure, the intraocular pressure, on the surface of the retina. [Sigal et al. Biomech Model Mechanobiol, 8(2):85-98, Apr 2009] (adapted from an illustration from NIH)

 

Goals

The objective of the Laboratory of Ocular Biomechanics is to study the eye as a biomechanical structure. More specifically our work is aimed at identifying the causes of glaucoma, with the ultimate intention of finding a way to prevent vision loss.