Lab logo

Laboratory of
Ocular Biomechanics

University of Pittsburgh











Latest News

5/17: New paper accepted

  • "Effects of collagen microstructure and material properties on the deformation of the neural tissues of the lamina cribrosa"
    by Acta Biomaterialia.

5/17: New paper accepted

  • "Whole-globe biomechanics using high-field MRI"
    by Experimental Eye Research.

  • In collaboration with Kevin Chan, New York University.

5/17: New paper accepted

  • "Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers"
    by IOVS.

5/17: Six poster presentations at ARVO

  • Meeting of the Association for Research in Vision and Ophthalmology, Baltimore, MD, May 7-11, 2017.

4/17: Congratulations Shweta Ravichandar, Katriona Blezy, Kelly Appleton, and Roy Tan Park Sung

3/17: New paper accepted (link)

  • "Thick prelaminar tissue decreases lamina cribrosa visibility"
    by IOVS.

  • In collaboration with Gadi Wollstein, Joel Schuman and the Glaucoma Imaging Group at New York University.

3/17: New paper accepted (journal)

  • "An imaged-based inverse finite element method to determine in-vivo mechanical properties of human trabecular meshwork"
    by Journal for Modeling in Ophthalmology.

  • In collaboration with R Amini, AD Pant, L Kagemann and JS Schuman.

3/17: New review paper accepted (link)

  • "Biomechanical aspects of axonal damage in glaucoma: A brief review"
    by Experimental Eye Research.

  • In collaboration with C. Stowell, C Burgoyne, ER Tamm, CR Ethier and the Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants.

3/17: New review paper accepted (link)

  • "Biological aspects of axonal damage in glaucoma: A brief review"
    by Experimental Eye Research.

  • In collaboration with ER Tamm, CR Ethier and the Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants.

Active projects
Click images for more info.

Why biomechanics of the eye?

In our daily lives we rarely think of the eye as a biomechanical structure. The eye, however, is a remarkably complex structure with biomechanics involved in many of its functions. For our eyes to be able to track moving objects, for example, requires a delicate balance of the forces exerted by several muscles. Forces are also responsible for deforming the lens and allow focusing. A slight imbalance between the forces and tissue properties may be enough to alter or even preclude vision. These effects may take place quickly or over long periods, even years. Understanding ocular biomechanics is therefore important for preventing and treating vision loss.

 

Eye diagram

Schematic cross-section through a human eye. Light enters the eye through the cornea, passes through the pupil, lens and vitreous humour and strikes the retina, where it is absorbed. Retinal nerve fibers transmit visual information to the brain. These fibers converge at the optic nerve head region, exit the eye through the scleral canal, and form the optic nerve. The lamina cribrosa is a porous structure spanning the scleral canal. The vitreous chamber is filled with the vitreous humor, which exerts a pressure, the intraocular pressure, on the surface of the retina. [Sigal et al. Biomech Model Mechanobiol, 8(2):85-98, Apr 2009] (adapted from an illustration from NIH)

 

Goals

The objective of the Laboratory of Ocular Biomechanics is to study the eye as a biomechanical structure. More specifically our work is aimed at identifying the causes of glaucoma, with the ultimate intention of finding a way to prevent vision loss.