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Laboratory of
Ocular Biomechanics

University of Pittsburgh

NEWS

For full details on manuscripts, click the publications tab.

May, 2017

  • New paper accepted

    • "Effects of collagen microstructure and material properties on the deformation of the neural tissues of the lamina cribrosa"
      by Acta Biomaterialia.

  • New paper accepted

    • "Whole-globe biomechanics using high-field MRI"
      by Experimental Eye Research.

    • In collaboration with Kevin Chan, New York University.

  • New paper accepted

    • "Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers"
      by IOVS.

  • Four podium presentations

    • University of Pittsburgh Postdoctoral Association (UPPDA) Data and Dine Symposium, Pittsburgh, PA, May 16, 2017

  • Six poster presentations

    • Meeting of the Association for Research in Vision and Ophthalmology, Baltimore, May 7-11, 2017

  • Welcome Junchao Wei, PhD

    • Joined our lab as a postdoctoral fellow

  • Jacob Wallace

    • Has left our lab to study Medicine. Good luck Jake!


April, 2017

  • Congratulations Huong Tran

    • Awarded a MS in Bioengineering.

  • Congratulations Shweta Ravichandar, Katriona Blezy, Kelly Appleton, and Roy Tan Park Sung

  • Poster Presentation

    • 2017 ISMRM 2017, Honolulu, HI, April 22-27 (in collaboration with Kevin C. Chan from NYU)

  • One podium and one poster presentation

    • Computational and Mathematical Biomedical Engineering, Pittsburgh, PA, April 10-12, 2017.


March, 2017

  • New paper accepted (link)

    • "Thick prelaminar tissue decreases lamina cribrosa visibility"
      by IOVS.

    • In collaboration with Gadi Wollstein, Joel Schuman and the Glaucoma Imaging Group at New York University.

  • New paper accepted (journal)

    • "An imaged-based inverse finite element method to determine in-vivo mechanical properties of human trabecular meshwork"
      by Journal for Modeling in Ophthalmology.

    • In collaboration with R Amini, AD Pant, L Kagemann and JS Schuman.

  • New review paper accepted (link)

    • "Biomechanical aspects of axonal damage in glaucoma: A brief review"
      by Experimental Eye Research.

    • In collaboration with C. Stowell, C Burgoyne, ER Tamm, CR Ethier and the Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants.

  • New review paper accepted (link)

    • "Biological aspects of axonal damage in glaucoma: A brief review"
      by Experimental Eye Research.

    • In collaboration with ER Tamm, CR Ethier and the Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants.


February, 2017

  • New paper accepted (link)

    • "Correlation between cerebral hemodynamic and perfusion pressure changes in non-human primates"
      by SPIE Proceedings.

    • In collaboration with Alex Ruesch and Jana Kainerstorfer from Carnegie Mellon University, Gadi Wollstein from New York University and Samantha Nelson and Matt Smith from the University of Pittsburgh.


January, 2017

  • Cover of Investigative Ophthalmology & Visual Science (link)

    • "Collagen Architecture of the Posterior Pole:
      High-Resolution Wide Field of View Visualization and Analysis Using Polarized Light Microscopy"

  • New paper accepted (link)

    • "Mapping in-vivo optic nerve head strains caused by intraocular and intracranial pressure"
      by SPIE Proceedings.

  • Two podium presentations (one invited)

    • SPIE Photonics West, San Francisco, California, Jan 28 - Feb 2, 2017.

  • Oxyopia lecture (invited)

    • University of California at Berkeley, California, Jan 27, 2017.


December, 2016

  • Four podium presentations

    • BioE Intramural Internship: Morgan Austin, Emma Hudertmark, Nick Krall and Felipe Suntaxi.

  • New paper accepted

    • "Development of computational tools for analyzing 3D in vivo deformations of monkey optic nerve head""
      by Ingenium.

    • Read the paper here.

  • New paper accepted

    • "Collagen architecture of the posterior pole; high-resolution, wide-field-of-view visualization and analysis using polarized light microscopy"
      by Investigative Ophthalmology and Visual Science.


October, 2016

  • Two poster presentations

    • BMES 2016 - Biomedical Engineering Society Annual Meeting, Minneapolis, MN. Oct 5-8, 2016.

  • Three poster presentations

    • Science 2016: Game Changers, Pittsburgh, PA, October 19-21, 2016.


September, 2016

  • Invited seminar

    • National University of Singapore, Singapore.

  • Podium presentation

    • XXII Biennial Meeting of the International Society for Eye Research, Tokyo Japan.


August, 2016

  • Welcome Yi (Jason) Hua, PhD

    • Joined our laboratory as a post-doctoral fellow.

  • Welcome Po Lam

    • Joined our laboratory as a research assistant.

  • New paper accepted

    • "Non-invasive MRI Assessments of Tissue Microstructures and Macromolecules in the Eye upon Biomechanical or Biochemical Modulation"
      by Scientific Reports. In collaboration with Kevin C. Chan.


July, 2016

  • New paper accepted

    • "Experimental glaucoma causes optic nerve head neural rim tissue compression: a potentially important mechanism of axon injury"
      by Investigative Ophthalmology and Visual Science. In collaboration with Brad Fortune.

  • New paper accepted

  • Welcome Bryn Brazile, PhD

    • Joined our laboratory as a post-doctoral fellow.

  • Welcome Bin Yang, PhD

    • Joined our laboratory as a post-doctoral fellow.

  • Best wishes to Danielle Hu

    • She is leaving our lab to start medical school. Good luck Danielle!


June, 2016

  • Two podium and a poster presentations

    • 2016 SB3C - Summer Biomechanics, Bioengieering and Biotransport Conference, National Harbor, Maryland. June 29 - July 2, 2016

  • Five poster presentations

    • 2016 Annual International Conference on Vision Restoration: Regenerative Medicine in Ophthalmology, Pittsburgh, PA, June 20-21, 2016

  • New paper accepted


May, 2016

  • Special Chair Guest Lecture

    • Department of Ophthalmology, University of Michigah, Ann Arbor, MI, May 23, 2016

  • Poster presentation

    • University of Pittsburgh Postdoctoral Association (UPPDA) Data and Dine Symposium, Pittsburgh, PA, May 17, 2016

  • Ground Rounds Lecture

    • Stony Brook Department of Ophthalmology, Stony Brook, NY, May 12, 2016

  • Welcome Jacob Wallace and Rafique Khan

    • Joined our laboratory as research assistants

  • Four podium and eight poster presentations at ARVO

    • Meeting of the Association for Research in Vision and Ophthalmology, Seattle, WA, May 1-5, 2016


April, 2016

  • One podium and three poster presentations at ARVO Imaging

    • ARVO Imaging in the Eye Conference, Seattle, WA, April 30, 2016

  • Congratulations Alexander Mace, Zeyu Tong and Jinxian Zhao

    • 2nd place in the Swanson School of Engineering Design Expo April 2016

  • Congratulations Andrew Voorhees

    • Awarded a second year of support from the Department of Ophthalmology's Interdisciplinary Visual Sciences Training Program

  • Congratulations Felipe Suntaxi

    • Awarded a 2016 Summer Research Internship By the Department of Bioengineering

  • New paper accepted

    • "Decreased lamina cribrosa beam thickness and pore diameter relative to distance from the central retinal vessel trunk"
      by IOVS (Investigative Ophthalmology and Visual Science). In collaboration with the Glaucoma Imaging Group.

  • Invited podium presentation

    • Department of Biomedical Engineering, The Ohio State University

  • Congratulations Ziyi Zhu

    • Awarded a 2016 Summer Research Fellowship By the Swanson School of Engineering


March, 2016

  • Postdoc position in elastography and image registration Closed

    Postdoc or research assistant position in structured illumination Closed

  • Two invited podium presentations

    • New York University Department of Ophthalmology and Tandon School of Engineering, New York NY, March 21, 2016

  • One podium and three poster presentations

    • McGowan Institute for Regenerative Medicine Annual Retreat, Farmington PA, March 6-8, 2016

  • New paper accepted

  • Welcome Vikram Gomatam, PhD

    • Joined our laboratory as a visiting research fellow


February, 2016

January, 2016

  • New paper accepted

    • "MAPS - a Magic Angle Positioning System for Enhanced Imaging in High-Field Small-Bore MRI"
      by Journal of Medical Robotics Research.

  • Welcome Spring MEMS 1043 Senior Design Project students

    • Alexander Mace, Zeyu Tong and Jingxian Zhao

  • Welcome Spring 2016 Undergraduate Research students

    • Karlie Brasch (FER), Jennifer Panza (FER), Emma Chen (FER), Brienna Roys (FER), Jin Yu Li (FER), Shumeng Yang and Eric Sou Ying Dong


December, 2015

  • Congratulations Joshua Selling, Morgan Skapik, Nicholas Cox and Rachel Rohr

    • 2nd place in the Swanson School of Engineering Design Expo 2015

  • Congratulations Cindy Jiao and Jacob Wallace

    • Awarded Brackenridge Fellowships by the University of Pittsburgh Honors College

  • New Post-Doctoral Position Available Closed

  • eCover of Biomedical Optics Express

    • "Polarization Microscopy for Characterizing Fiber Orientation of Ocular Tissues"
      has been selected for the eCover of the December 2015 issue
      by Biomedical Optics Express.


November, 2015

  • New paper accepted

    • "Use And Misuse of Laplace's Law in Ophthalmology"
      by IOVS (Investigative Ophthalmology and Visual Science).

  • Letter to the editor accepted

    • "A problem of proportions in OCT-based morphometry and a proposed solution"
      by IOVS (Investigative Ophthalmology and Visual Science).

October, 2015

  • New paper accepted

    • "Polarization Microscopy for Characterizing Fiber Orientation of Ocular Tissues"
      by Biomedical Optics Express.

  • Eight poster presentations at Science 2015

    • Science 2015- Unleashed!, Pittsburgh, PA, October 7-9, 2015

  • Poster presentation at BMES

    • Annual Meeting of the Biomedical Engineering Society, Tampa, Florida, October 7-10, 2015

September, 2015

  • Grant Awarded

    • R01 National Institutes of Health - PI: Sigal, PI:Wollstein, Co-I:Smith

  • Welcome new Fall 2015 Undergraduate research students

    • Cindy Jiao, Mikayla Ferchaw.

August, 2015

  • New Post-doctoral fellow position available Closed

    • Soft tissue biomechanics and imaging.

  • New Post-doctoral fellow position available Closed

    • Image Analysis.

  • Welcome Danielle Hu, BS

    •  Joined our laboratory as a research assistant.

July, 2015

June, 2015

  • One podium and two poster presentations at the Fox Vision Restoration Conference

    •  5th Annual Conference on Vision Restoration: Regenerative Medicine in Ophthalmology, Pittsburgh, PA, June 25-26, 2015.

  • Podium presentation by Ian at SB3C

    •  Summer Biomechanics, Bioengineering and Biotransport Conference, Snowbird, UT, June 17-20, 2015.

  • Two podium and poster presentations at Vision Research Day

    • Vision Research Day, UPMC Department of Ophthalmology, Pittsburgh, PA, June 18, 2015

  • Welcome Alexandra Judisch, MS

    •  Joined our laboratory as a systems analyst/programmer.

May, 2015

  • Welcome Andrew Voorhees, PhD

    •  Joined our laboratory as a post-doctoral fellow.

  • Nine podium and poster presentations at ARVO

    • Meeting of the Association for Research in Vision and Ophthalmology, Denver, CO, May 3-7, 2015.

  • Seven podium and poster presentations at ARVO Imaging

    • 2015 ARVO Imaging in the Eye Conference, Denver, CO, May 2, 2015.

  • New paper accepted

    • "Histogram Matching Extends Acceptable Signal Strength Range on Optical Coherence Tomography Images"
      by IOVS (Investigative Ophthalmology and Visual Science).
      In collaboration with the Glaucoma Imaging Group.

  • Welcome 2015 Summer undergraduate students

    • Michael Iasella, Garrett Grube, Jeremy Teichmann, Jennifer Ten Eyck, William Walters, Jacob Wallace, Yiyao Shi, David Tsui, Mason Lester, Andrew Levandoski, Zach Adgate, Yujie Mu and Jon Drobitch.

April, 2015

  • Congratulations Garrett Grube

    •  Awarded a Summer Research Internship by the Swanson school of engineering (co-supported by our lab).

  • Congratulations Jeremy Teichmann

    •  Awarded a Summer Research Internship by the Swanson school of engineering to work with Dr. Wollstein and our lab (co-supported by Dr. Wollstein and Dr. Sigal).

  • Two poster presentations

    •  University of Pittsburgh Bioengineering Day 2015: Sustainability in Biotechnology. April 16, 2015.

  • New paper accepted

    • "In vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System after Excitotoxic Retinal Injury with Multimodal MRI and OCT"
      by IOVS (Investigative Ophthalmology and Visual Science).
      In collaboration with Kevin C. Chan's Lab.

  • New position Closed

    • Research assistant (Co-supported by Ocular Biomechanics, Glaucoma Imaging and Visual Neuroscience Labs)

March, 2015

  • Invited presentation

    • Lasker / IRRF meeting. HHMI, Janelia Farms, March 8-11, 2015

  • Two poster presentations

    • McGowan Institute for Regenerative Medicine Annual Retreat, Farmington PA, March 8-10, 2015

February, 2015

  • Grant Awarded

    • Glaucoma Research Foundation Shaffer Grant (Smith PI, Sigal Co-I and Wollstein Co-I)

January, 2015

  • New Position Closed

    • Postdoctoral fellow in soft tissue biomechanics.

  • New Position Closed

    • Postdoctoral fellow in ophthalmic imaging.

  • New Position Closed

    • Programmer with image processing experience.

  • New paper accepted

    • "Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye" by Journal of Visualized Experiments.
      In collaboration with Larry Kagemann and the Glaucoma Imaging Group.

December, 2014

  • New paper published

    • "Parameters for lithium treatment are critical in its enhancement of fracture-healing
      in rodents" in Journal of Bone and Joint Surgery, American Volume.

October, 2014

  • Poster presentation at BMES

    • Annual Meeting of the Biomedical Engineering Society,
      San Antonio, Texas, October 22-25, 2014

  • Seven poster presentations at Science 2014

    • Science 2014: Sustain It!, Pittsburgh, PA, October 1-3, 2014

September, 2014

  • New paper accepted

    • "In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography" by IOVS (Investigaive Ophthalmology and Visual Science)

August, 2014

  • Grant Renewed

    • R01 National Institutes of Health - PI: Schuman, Sigal (Co-I)

  • Invited podium presentation at GRS

    • Glaucoma Research Society Meeting, Jackson Hole Wyoming, August 27-30, 2014

  • New paper accepted

    • "Application of Elliptic Fourier Analysis to Describe the Lamina Cribrosa Shape with Age and Intraocular Pressure", by Experimental Eye Research

July, 2014

  • New paper accepted

    • "Magic Angle-Enhanced MRI Of Fibrous Microstructures In Sclera And Cornea With And Without Intraocular Pressure Loading" by IOVS (Investigative Ophthalmology and Visual Science)

  • Three invited podium presentations at ISER

    • XXI meeting of the International Society for Eye Research, San Francisco, CA, July 20-24, 2014

  • Podium presentation at the WCB

    • 7th World Congress of Biomechanics, Boston, MA, July 6-11, 2014

June, 2014

  • Congratulations Celeste Gomez

    • Awarded a Fight for Sight summer student fellowship

    • Completed her BSc degree in Biology

  • Congratulations James Constantin and Yuqi Wang

    • Awarded support for summer research by the Department of bioengineering, University of Pittsburgh

  • Congratulations Saundria Moed

    • Awarded support for summer research by the Swanson school of engineering, University of Pittsburgh

  • Congratulations Yoonsoo Kim

    • Completed his BSc degree in Biology

  • Three poster presentations on Vision Restoration

    • Vision Restoration: Regenerative Medicine in Ophthalmology, Pittsburgh, PA, June 23-24, 2014

  • Three poster and podium presentations at Vision Research Day

    • Vision Research Day, UPMC Department of Ophthalmology, Pittsburgh, PA, June 13, 2014

May, 2014

  • New paper accepted

    • "Recent Advances in OCT Imaging of the Lamina Cribrosa" by British Journal of Ophthalmology

  • Welcome Summer Research Students

    • 13 Undergraduate students will participate in summer research projects

  • Twelve podium and poster presentations at ARVO

    • Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Orlando, FL, May 4-8, 2014.

  • Four podium and poster presentations at ISIE

    • Meeting of the International Society for Imaging of the Eye (ISIE), Orlando, FL, May 3, 2014.

    • Congratulations Ninj and Leon on your excellent talks!

April, 2014

  • New paper accepted

    • "Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects" by Current Eye Research.

March, 2014

  • Grant Awarded

    • R01 National Institutes of Health - PI: Sigal

  • New paper accepted

    • "Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture" by PLOS One.

  • Three poster presentations at the McGowan retreat.

    • McGowan Institute 2014 Scientific Retreat, Nemacolin Woodlands, Farmington, PA March 9-11, 2014

February, 2014

  • New paper accepted

    • "A Method to Estimate Biomechanics and Mechanical Properties of Optic Nerve Head Tissues From Parameters Measurable Using Optical Coherence Tomography" by IEEE Transactions on Medical Imaging.

  • New paper accepted

    • "Characterization of Schlemm’s Canal Cross-Sectional Area" by Biomedical Optics Express.

  • New paper accepted

    • "IOP Elevation Reduces Schlemm’s Canal Cross-sectional Area" by IOVS.

  • New paper accepted

    • "Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography" by Biomedical Optics Express.

January, 2014

  • New paper accepted

    • "Gold Nanorods as a Contrast Agent for Doppler Optical Coherence Tomography" accepted for publication by PLOS One.

  • New paper accepted